INTERMOLECULAR BENZYNE CYCLOADDITION (IBC), A VERSATILE APPROACH TO BENZOPHENANTHRIDINE ANTITUMOR ALKALOIDS - FORMAL SYNTHESIS OF NITIDINE AND CHELERYTHRINE

被引：35

作者：

MARTIN, G

GUITIAN, E

CASTEDO, L

SAA, JM

机构：

[1] UNIV SANTIAGO,DEPT QUIM ORGAN,E-15706 SANTIAGO,SPAIN

[2] UNIV SANTIAGO,CSIC,SECC ALCALOIDES,E-15706 SANTIAGO,SPAIN

[3] UNIV ILLES BALEARS,DEPT QUIM,E-07071 PALMA DE MALLORCA,SPAIN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 22期

关键词：

D O I：

10.1021/jo00048a024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to the synthesis of benzophenanthridine alkaloids is described which is based on cycloaddition of arynes to pyrrolinediones, the pyrrolinediones behaving as aza diene equivalents. The synthesis of 2,3,8,9-substituted benzophenanthridines and the regioselective synthesis of a 2,3,7,8-substituted benzophenanthridine were performed. The formal synthesis of chelerythrine and the antitumor alkaloid nitidine is described.

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页码：5907 / 5911

页数：5

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