A HUMAN DOPAMINE TRANSPORTER CDNA PREDICTS REDUCED GLYCOSYLATION, DISPLAYS A NOVEL REPETITIVE ELEMENT AND PROVIDES RACIALLY-DIMORPHIC TAQI RFLPS

被引：162

作者：

VANDENBERGH, DJ

PERSICO, AM

UHL, GR

机构：

[1] NIDA,ADDICT RES CTR,MOLEC NEUROBIOL LAB,POB 5180,BALTIMORE,MD 21224

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21224

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21224

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 15卷 / 1-2期

关键词：

COCAINE; DRUG RECEPTOR; PARKINSONISM; TANDEM REPEAT; TOURETTES SYNDROME;

D O I：

10.1016/0169-328X(92)90165-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3' untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.

引用

页码：161 / 166

页数：6

共 23 条

[1] MOLECULAR-BASIS OF MYOTONIC-DYSTROPHY - EXPANSION OF A TRINUCLEOTIDE (CTG) REPEAT AT THE 3' END OF A TRANSCRIPT ENCODING A PROTEIN-KINASE FAMILY MEMBER
BROOK, JD
MCCURRACH, ME
HARLEY, HG
BUCKLER, AJ
CHURCH, D
ABURATANI, H
HUNTER, K
STANTON, VP
THIRION, JP
HUDSON, T
SOHN, R
ZEMELMAN, B
SNELL, RG
RUNDLE, SA
CROW, S
DAVIES, J
SHELBOURNE, P
BUXTON, J
JONES, C
JUVONEN, V
JOHNSON, K
HARPER, PS
SHAW, DJ
HOUSMAN, DE
[J]. CELL, 1992, 68 (04) : 799 - 808
[2] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX
DEVEREUX, J
HAEBERLI, P
SMITHIES, O
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (01) : 387 - 395
[3] GENETICS OF ALCOHOLISM
DEVOR, EJ
CLONINGER, CR
[J]. ANNUAL REVIEW OF GENETICS, 1989, 23 : 19 - 36
[4] FEINBERG A, 1982, ANAL BIOCHEM, V132, P6
[5] VARIATION OF THE CGG REPEAT AT THE FRAGILE-X SITE RESULTS IN GENETIC INSTABILITY - RESOLUTION OF THE SHERMAN PARADOX
FU, YH
KUHL, DPA
PIZZUTI, A
PIERETTI, M
SUTCLIFFE, JS
RICHARDS, S
VERKERK, AJMH
HOLDEN, JJA
FENWICK, RG
WARREN, ST
OOSTRA, BA
NELSON, DL
CASKEY, CT
[J]. CELL, 1991, 67 (06) : 1047 - 1058
[6] CLONING AND FUNCTIONAL-CHARACTERIZATION OF A COCAINE-SENSITIVE DOPAMINE TRANSPORTER
GIROS, B
ELMESTIKAWY, S
BERTRAND, L
CARON, MG
[J]. FEBS LETTERS, 1991, 295 (1-3): : 149 - 154
[7] CLONING AND EXPRESSION OF A COCAINE-SENSITIVE RAT DOPAMINE TRANSPORTER
KILTY, JE
LORANG, D
AMARA, SG
[J]. SCIENCE, 1991, 254 (5031) : 578 - 579
[8] KITAYAMA S, IN PRESS P NATL ACAD
[9] KITAYAMA S, UNPUB J BIOL CHE
[10] DOPAMINE TRANSPORTER - DEGLYCOSYLATION WITH EXOGLYCOSIDASES AND ENDOGLYCOSIDASES
LEW, R
GRIGORIADIS, D
WILSON, A
BOJA, JW
SIMANTOV, R
KUHAR, MJ
[J]. BRAIN RESEARCH, 1991, 539 (02) : 239 - 246

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