TRANSIENT EXPRESSION OF THE NR2C SUBUNIT OF THE NMDA RECEPTOR IN DEVELOPING RAT-BRAIN

被引：51

作者：

POLLARD, H

KHRESTCHATISKY, M

MOREAU, J

BENARI, Y

机构：

[1] INSERM U 29, Laboratoire de Neurobiologie et Physiologie du Développement, Hopital de Port Royal, Paris, 75014

来源：

NEUROREPORT | 1993年 / 4卷 / 04期

关键词：

HIPPOCAMPUS; DEVELOPMENT; NMDA RECEPTORS; NR2C SUBUNIT; MESSENGER RNA; INSITU HYBRIDIZATION;

D O I：

10.1097/00001756-199304000-00018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

PHARMACOLOGICALLY distinct NMDA-glutamate receptor subtypes have been reported in brain. We have studied the developmental expression of the mRNA encoding the NMDA receptor NR2C subunit in the rat brain by in situ hybridization. In contrast with the adult where no hybridization signal was detected in the hippocampus, a significant signal was seen in this formation during a restricted developmental period (P7-P14). The labelling covered large parts of the hippocampus including in particular the stratum radiatum, pyramidal and oriens layers of the CA1 area. The role of the NR2C subunit in neonatal NMDA receptor properties is discussed.

引用

页码：411 / 414

页数：4

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