SYNTHESIS AND BIOLOGICAL-ACTIVITY OF CONFORMATIONALLY CONSTRAINED 4A-PHENANTHRENEAMINE DERIVATIVES AS NONCOMPETITIVE NMDA ANTAGONISTS

被引：5

作者：

MALONE, TC

ORTWINE, DF

JOHNSON, G

PROBERT, AW

机构：

[1] Parke-Davis Pharmaceutical Research Division Warner Lambert Company, Ann Arbor, MI 48105

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80090-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses, biological activity, and molecular modeling of conformationally constrained derivatives of cis-1,3,4,9,10,10a-hexahydro-N-methyl-4a(2H)-phenanthreneamine (PD 134365), a new conformationally rigid noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, are described.

引用

页码：49 / 54

页数：6

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