MOLECULAR MODELING INDICATES THAT 2 CHEMICALLY DISTINCT CLASSES OF ANTI-MITOTIC HERBICIDE BIND TO THE SAME RECEPTOR SITE(S)

被引：23

作者：

ELLIS, JR

TAYLOR, R

HUSSEY, PJ

机构：

[1] UNIV LONDON, ROYAL HOLLOWAY & BEDFORD NEW COLL, DEPT BIOCHEM, EGHAM TW20 0EX, SURREY, ENGLAND

[2] ZENECA SEEDS & AGROCHEM, JEALOTTS HILL RES STN, BRACKNELL RG12 6EY, BERKS, ENGLAND

来源：

PLANT PHYSIOLOGY | 1994年 / 105卷 / 01期

关键词：

D O I：

10.1104/pp.105.1.15

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Dinitroaniline and phosphorothioamidate herbicides disrupt microtubule assembly from tubulin protein dimers and thereby halt microtubule-based processes such as mitosis in plant cells. Despite the contrasting chemical properties of dinitroaniline and phosphorothioamidate herbicides, a three-dimensional molecular analysis revealed remarkable electrostatic similarity between these two classes of herbicide. From these data it is proposed that dinitroaniline and phosphorothioamidate herbicides share common binding site(s) in the plant cell.

引用

页码：15 / 18

页数：4

共 33 条

[1] SYSTEMATIC ANALYSIS OF STRUCTURAL DATA AS A RESEARCH TECHNIQUE IN ORGANIC-CHEMISTRY [J].