CHIRAL DENDRIMERS FROM TRIS(HYDROXYMETHYL)METHANE DERIVATIVES

The first dendrimer with a chiral core and chiral branch units (2) is readily available from triols of the type 1. Attachment of spacer groups or direct etherification of 1 with benzylic bromides lead to first, second, and third generation chiral dendrimers. The molecular weights of the fully characterized dendrimers range between 1000 and 3000 Da. The dendrimer 2, built up from four chiral building blocks, is one out of 4096 possible stereoisomers. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany