HUMAN-B CELL INTERLEUKIN-10

被引：43

作者：

BENJAMIN, D

PARK, CD

SHARMA, V

机构：

[1] Division of Hematology and Oncology, The Arthur G. James Cancer Hospital and Research Institute, Comprehensive Cancer Center, The Ohio State University, Columbus, OH

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 12卷 / 3-4期

关键词：

INTERLEUKIN-10; AIDS; LYMPHOKINE; BCRF1; LYMPHOMA;

D O I：

10.3109/10428199409059591

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin 10 (IL-10) is a novel lymphokine which exhibits strong DNA and amino-acid sequence homology to BCRF1, an open reading frame in the Epstein-Barr virus genome. Using a wide panel of EBV positive and EBV negative cell lines, it has been shown that EBV positive B cell lines derived from patients with AIDS and Burkitt's lymphoma (AABCL) secrete large quantities of B cell IL-10, compared-with EBV-positive B cell lines obtained from patients with undifferentiated lymphomas of Burkitt's and non-Burkitt's types. In contrast, EBV-negative B cell lines do not express IL-10 by Northern blot analysis, ELISA or even PCR. B cell IL-10 is confined to a narrow window in the B cell differentiation pathway, and whereas IL-10 expression is detected in mature and preplasmacytic stages, none of the pro-B, pre-B, or myeloma cell lines produce IL-10. EBV exerts direct effect on the production of B cell IL-10, and purified tonsillar B cells infected with EBV were triggered to secrete IL-10. The large amount of IL-10 secreted by B cells derived from AIDS-related lymphomas suggests that HIV-1 also exerts direct effect on IL-10 secretion. B cell IL-10 may function as autocrine growth factor for B cell lymphomas, and both IL-10 and BCRFI seem to be involved in the pathophysiology of non-Hodgkin's lymphomas.

引用

页码：205 / 210

页数：6

共 45 条

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