CYCLIC DIPEPTIDES - A STEREOCONTROLLED SYNTHESIS OF (2S,3R,6R) AND (2R,3R,6R)-6-TERT-BUTOXYCARBONYLAMINO-3-METHOXYCARBONYL-2-METHYL-5-OXOPERHYDRO-1,4-THIAZEPINE

被引：8

作者：

CORELLI, F ^{[1
]}

CRESCENZA, A ^{[1
]}

DEI, D ^{[1
]}

TADDEI, M ^{[1
]}

BOTTA, M ^{[1
]}

机构：

[1] DIPARTIMENTO CHIM U SCHIFF,I-50121 FLORENCE,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 08期

关键词：

D O I：

10.1016/0957-4166(94)80115-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A stereselective synthesis of the title compounds, starting from commercially available amino acids, is described. The absolute stereochemistry of 3a and 3b has been deduced on the basis of H-1 NMR and chemical degradation studies. The formation of only these two isomers has been rationalized in terms of molecular mechanics calculations.

引用

页码：1469 / 1472

页数：4

共 6 条

[1] THE SYNTHESIS OF 6-AMINO-5-OXO-7-PHENYL-1,4-OXAZEPINES AS CONFORMATIONALLY CONSTRAINED GAUCHE (-) DIPEPTIDE MIMETICS [J].