EFFECT OF A BULK FORMING LAXATIVE ON THE BIOAVAILABILITY OF CARBAMAZEPINE IN MAN

被引：12

作者：

ETMAN, MA

机构：

[1] Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 16期

关键词：

D O I：

10.3109/03639049509070866

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The influence of a bulk forming laxative consisting of 3.5g. Ispaghula Husk (Plantago seeds) on the bioavailability of Carbamazepine from commercial tablets was studied in four healthy male volunteers. The drug was administered as a single oral dose of 200 mg. Evaluation of the absorption was done by means of the plasma concentration measurements. Seven blood samples were collected over a 24-h period following carbamazepine administration and the drug plasma concentrations were determined by HPLC. The data were statistically analyzed by the t-test for paired observations and were subjected to a stripping computer program to obtain the relevant bioavailability values.

引用

页码：1901 / 1906

页数：6

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