METABOLISM OF [ORDRAM-[RING-C-14] (MOLINATE) IN RAT .1. BALANCE AND TISSUE RESIDUE STUDY

Excretion of 14C after administration of [ring-14C]Ordram, S-ethyl hexahydro[2-14C]azepine-l-carbothioate, to rats was rapid, with approximately 97% of an oral dose (72 mg/kg) being excreted within 48 h after dosing. The major routes of excretion were via the urine (~88%, urine + cage wash) and feces (~11%). Less than 1 % of the dose was detected in the sodium hydroxide air traps. No significant differences were observed between the rates and routes of excretion from male and female rats. Similarly, no significant differences in residual tissue 14C attributable to sex effects were observed. With the exception of blood, residues associated with most tissues substantially decreased over the 7-day period after dosing. Whole-body residues decreased from an average of 13.8% of the administered 14C at 1 day to 3.7% after 7 days. Seven-day blood residues were dose dependent, decreasing markedly from 40.1 ppm Ordram equivalents at a relatively high dose of 80 mg/kg to less than 1 ppm at a dose of 5 mg/kg. © 1978, American Chemical Society. All rights reserved.