PROSTAGLANDINS IN THE BRAIN OF RATS GIVEN, ACUTELY, AND CHRONICALLY, A HYPERTHERMIC DOSE OF MET-ENKEPHALIN

被引：25

作者：

SCOTO, GM

SPADARO, C

SPAMPINATO, S

ARRIGOREINA, R

FERRI, S

机构：

[1] Institute of Pharmacology and Pharmacognosy, University of Catania

来源：

PSYCHOPHARMACOLOGY | 1979年 / 60卷 / 02期

关键词：

Brain; Met-enkephalin; Prostaglandins; Rat; Temperature;

D O I：

10.1007/BF00432297

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An enhanced prostaglandinlike activity is shown in homogenates of brain from rats treated intracerebroventricularly with 100 μg of metenkephalin. The increase is significantly reduced by naloxone pretreatment. A relationship is proposed between generation of prostaglandins in the brain following met-enkephalin administration and hyperthermic effect of the opiatelike factor in the rat. Normalization of prostaglandinlike activity following chronic administration of met-enkephalin in the rat may also account for the development of tolerance to its thermic effect. © 1979 Springer-Verlag.

引用

页码：217 / 219

页数：3

共 16 条

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