EMETIC ACTIVITY OF ZACOPRIDE IN FERRETS AND ITS ANTAGONISM BY PHARMACOLOGICAL AGENTS

被引：22

作者：

SANCILIO, LF

PINKUS, LM

JACKSON, CB

MUNSON, HR

机构：

[1] AH ROBINS CO INC,RES LABS,DEPT PHARMACOL,RICHMOND,VA 23261

[2] AH ROBINS CO INC,RES LABS,DEPT MOLEC BIOL,RICHMOND,VA 23261

[3] AH ROBINS CO INC,RES LABS,DEPT CHEM RES,RICHMOND,VA 23261

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 181卷 / 03期

关键词：

(Ferret); (Oral); 5-HT antagonists; Benzamides (zacopride); Emesis;

D O I：

10.1016/0014-2999(90)90094-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Zacopride administered orally was more emetic in fed than in fasted ferrets. The emetic activity of zacopride (0.1 mg/kg p.o.) was inhibited (100%) by 0.1 mg/kg i.p. of zacopride and 1 mg/kg i.p. of ICS 205-930. Haloperidol (3.16 mg/kg i.p.) and prochlorperazine (3.16 mg/kg i.p.) were weakly effective. N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, a 5-HT1P antagonist, was inactive. Thus, the emetic activity of zacopride, like that of cisplatin, is blocked by 5-HT3 receptor antagonists. © 1990.

引用

页码：303 / 306

页数：4

共 11 条

[1] EVIDENCE FOR AN EXTRA-ABDOMINAL SITE OF ACTION FOR THE 5-HT3 RECEPTOR ANTAGONIST BRL24924 IN THE INHIBITION OF RADIATION-EVOKED EMESIS IN THE FERRET [J].