ESTIMATING BIOCONCENTRATION FACTORS AND HALF-LIVES IN HUMANS USING PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING - 2,3,7,8-TCDD

被引：4

作者：

WEBSTER, T ^{[1
]}

CONNETT, P ^{[1
]}

机构：

[1] ST LAWRENCE UNIV,DEPT CHEM,CANTON,NY 13617

来源：

CHEMOSPHERE | 1991年 / 23卷 / 11-12期

关键词：

BIOCONCENTRATION; HALF-LIFE; HUMANS; 2,3,7,8-TCDD; PHARMACOKINETIC MODELING;

D O I：

10.1016/0045-6535(91)90023-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A bioconcentration factor and a half-life of 2,3,7,8-TCDD in 70 kg reference humans are estimated from a physiologically based pharmacokinetic model. The system of differential equations is solved using eigenvalue methods. The results are approximated using a standard first-order bioconcentration equation.

引用

页码：1763 / 1768

页数：6

共 12 条

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