THE GENETIC-BASIS OF RO AND LA ANTIBODY-FORMATION IN SYSTEMIC LUPUS-ERYTHEMATOSUS - RESULTS OF A MULTICENTER STUDY

被引：22

作者：

HARTUNG, K

EHRFELD, H

LAKOMEK, HJ

COLDEWEY, R

LANG, B

KRAPF, F

MULLER, R

SCHENDEL, D

DEICHER, H

SEELIG, HP

ALBERT, E

BAUR, M

CORVETTA, A

FREY, J

KALDEN, JR

DELANGE, GG

PETER, HH

PIRNER, K

ROTHER, R

SCHNEIDER, P

SEUCHTER, S

SPATH, P

SPECKER, C

STANGEL, W

STANNATKIESSLING, S

机构：

[1] UNIV HANOVER,DEPT MED,W-3000 HANNOVER,GERMANY

[2] UNIV HANOVER,DEPT IMMUNOL & BLOOD BANK,W-3000 HANNOVER,GERMANY

[3] UNIV ERLANGEN NURNBERG,W-8520 ERLANGEN,GERMANY

[4] UNIV FREIBURG,W-7800 FREIBURG,GERMANY

[5] UNIV DUSSELDORF,W-4000 DUSSELDORF 1,GERMANY

[6] UNIV MUNICH,W-8000 MUNICH 2,GERMANY

[7] PRIVATE INST IMMUNOL & MOLEC GENET,KARLSRUHE,GERMANY

来源：

RHEUMATOLOGY INTERNATIONAL | 1992年 / 11卷 / 06期

关键词：

SYSTEMIC LUPUS ERYTHEMATOSUS; RO AND LA ANTIBODIES; MULTICENTER STUDY; GENETICS;

D O I：

10.1007/BF00301501

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antibodies against Ro and La, including recombinant La and recombinant 60 kD-Ro, were determined by counter immunoelectrophoresis and ELISA in over 300 central European systemic lupus erythematosus (SLE) patients. The presence of both Ro and La antibodies was strongly associated with the MHC haplotype B8-C4AQ0-DR3-DQ2, the association being strongest for DR3. After exclusion of all B8-DR3 positive patients only DR3 positive patients still showed an increased incidence of Ro and La antibodies, suggesting DR3 as the primary association factor. High titers of La antibody, but not of 60 kD-Ro antibody, were also significantly associated with the presence of DR3. Other DR and DQ antigens or heterozygous DQ combinations were not significantly associated with Ro and La antibodies.

引用

页码：243 / 249

页数：7

共 56 条

[1] INTERRELATIONSHIPS OF HLA-DR, MB, AND MT PHENOTYPES, AUTOANTIBODY EXPRESSION, AND CLINICAL-FEATURES IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].