PEPTIDE MEMBRANE INTERACTIONS AND A NEW PRINCIPLE IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS

被引:117
作者
SCHWYZER, R
机构
[1] Department of Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH), Zürich
关键词
D O I
10.1002/bip.360310624
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ideas about "active conformations" of peptides as the basis of their biological action are reviewed and put into perspective with recent work on the possible role of the lipid phase of the target cell membrane in mediating receptor subtype selectivity.
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页码:785 / 792
页数:8
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