FACILITATION OF SPECIFIC TOLERANCE INDUCTION IN ADULT MICE BY RS-61443

被引:46
作者
HAO, LM
CALCINARO, F
GILL, RG
EUGUI, EM
ALLISON, AC
LAFFERTY, KJ
机构
[1] UNIV COLORADO,HLTH SCI CTR,BARBARA DAVIS CTR CHILDHOOD DIABET,DENVER,CO 80262
[2] SYNTEX INC,PALO ALTO,CA 94304
关键词
D O I
10.1097/00007890-199203000-00020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
RS-61443 is an immunosuppressive agent that facilitates pancreatic islet allograft acceptance in two mouse strain combinations (BALB/c --> CBA and C57Bl/6J --> BALB/c). A remarkable feature of this agent is its ability to facilitate long-term graft acceptance after a short (30 days) period of treatment; following withdrawal of the agent 40-70% of islet allografts are maintained for an indefinite period. This long-term graft acceptance has been shown to result from specific tolerance induction in the recipient animal. The state of specific tolerance is an active rather than a passive form of tolerance, such as clonal deletion or anergy. Active tolerance induction is cyclosporine-sensitive, although cyclosporine enhances graft acceptance when used in combination therapy with RS-61443, this agent inhibits tolerance development under the influence of RS-61443.
引用
收藏
页码:590 / 595
页数:6
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