EXTENSIVE CUTANEOUS HYPERPIGMENTATION CAUSED BY MINOCYCLINE

被引:63
作者
PEPINE, M
FLOWERS, FP
RAMOSCARO, FA
机构
[1] UNIV FLORIDA, COLL MED, DIV DERMATOL & CUTANEOUS SURG, GAINESVILLE, FL 32611 USA
[2] VET ADM MED CTR, DERMATOL & CUTANEOUS SURG SECT, GAINESVILLE, FL 32602 USA
关键词
D O I
10.1016/0190-9622(93)70037-T
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
A 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2 1/2 years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal.
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页码:292 / 295
页数:4
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