STIMULATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EXPRESSION BY CERAMIDE

被引：16

作者：

PAPP, B ^{[1
]}

ZHANG, DZ ^{[1
]}

GROOPMAN, JE ^{[1
]}

BYRN, RA ^{[1
]}

机构：

[1] HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,DIV HEMATOL ONCOL,BOSTON,MA 02215

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1994年 / 10卷 / 07期

关键词：

D O I：

10.1089/aid.1994.10.775

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ceramide, an intracellular lipid mediator of tumor necrosis factor alpha (TNF-alpha) action, was studied for its effects on the expression of the proviral human immunodeficiency virus type 1 genome in latently infected myelomonocytic cell lines U-1(IIIB) and OM-10.1. Ceramide treatment resulted in a 20- to 100-fold enhancement of HIV production in these cells. Ceramide also enhanced the expression of the chloramphenicol acetyltransferase gene directed by a human immunodeficiency virus type 1 long terminal repeat in transfected U-937 cells, indicating that ceramide acts at the level of viral transcription. These observations suggest that the TNF-ceramide signaling system may be involved in the regulation of HIV expression in certain myeloid cell types.

引用

页码：775 / 780

页数：6

共 42 条

[1] TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 LEAD TO PHOSPHORYLATION AND LOSS OF I-KAPPA-B-ALPHA - A MECHANISM FOR NF-KAPPA-B ACTIVATION [J].

BEG, AA ;

FINCO, TS ;

NANTERMET, PV ;

BALDWIN, AS .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (06) :3301-3310

[2] MODULATION OF CELL-GROWTH AND DIFFERENTIATION BY CERAMIDE [J].

BIELAWSKA, A ;

LINARDIC, CM ;

HANNUN, YA .

FEBS LETTERS, 1992, 307 (02) :211-214

[3]

BIELAWSKA A, 1992, J BIOL CHEM, V267, P18493

[4]

BUTERA ST, 1993, J IMMUNOL, V150, P625

[5] OSCILLATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS SURFACE-RECEPTOR IS REGULATED BY THE STATE OF VIRAL ACTIVATION IN A CD4+ CELL MODEL OF CHRONIC INFECTION [J].

BUTERA, ST ;

PEREZ, VL ;

WU, BY ;

NABEL, GJ ;

FOLKS, TM .

JOURNAL OF VIROLOGY, 1991, 65 (09) :4645-4653

[6]

CLOUSE KA, 1989, J IMMUNOL, V142, P431

[7]

DBAIBO GS, 1993, J BIOL CHEM, V268, P17762

[8]

DOPPLER C, 1992, AIDS RES HUM RETROV, V8, P243

[9]

DRESSLER KA, 1990, J BIOL CHEM, V265, P14917

[10] TUMOR-NECROSIS-FACTOR-ALPHA ACTIVATES THE SPHINGOMYELIN SIGNAL TRANSDUCTION PATHWAY IN A CELL-FREE SYSTEM [J].

DRESSLER, KA ;

MATHIAS, S ;

KOLESNICK, RN .

SCIENCE, 1992, 255 (5052) :1715-1718

← 1 2 3 4 5 →