BONE-MARROW NITRIC-OXIDE PRODUCTION AND DEVELOPMENT OF ANEMIA IN TRYPANOSOMA BRUCEI-INFECTED MICE

被引:61
作者
MABBOTT, N [1 ]
STERNBERG, J [1 ]
机构
[1] UNIV ABERDEEN,DEPT ZOOL,ABERDEEN AB9 2TN,SCOTLAND
基金
英国惠康基金;
关键词
D O I
10.1128/IAI.63.4.1563-1566.1995
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mice infected with Trypanosoma brucei rapidly develop anemia, with the number of circulating erythrocytes reduced by 50% within a week after infection. The present study investigated the relationship between anemia and bone marrow nitric oxide (NO) production, Bone marrow cell populations from T. brucei-infected mice exhibited elevated levels of NO synthase activity which was inhibitable by N-G-nitro-L-arginine methyl ester. NO production was found to coincide,vith suppressed bone marrow T-cell proliferation in response to stimulation with the mitogen concanavalin A both in vitro and in vivo, As this indicated that NO may inhibit proliferation in other cell types, particularly hemopoietic precursors, we examined the role of NO in anemia during trypanosome infection. NO production correlated directly with the development of anemia, and treatment of infected mice with N-G-nitro-L-arginine methyl ester in vivo to systemically inhibit NO synthesis led to a significant reduction in the anemia, Thus, elevated NO production in the bone marrow of T. brucei-infected mice is likely to play a significant role in the anemia resulting from T. brucei infection.
引用
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页码:1563 / 1566
页数:4
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