MULTIPLE ADENOVIRUS SEROTYPES USE ALPHA-V INTEGRINS FOR INFECTION

The nucleotide sequence encoding the penton base integrin-binding domains of several human adenoviruses was obtained by homology PCR. Each of the penton base proteins contains a conserved Arg-Gly-Asp (RGD) sequence that is predicted to lie at the apex of two extended alpha helices. The penton base RGD domain promotes efficient infection of host cells by multiple adenovirus serotypes via interaction with cuv integrins, thus indicating that alpha v integrins play a central role in the entry of adenoviruses into host cells.