ADHESION MOLECULE EXPRESSION AND LYMPHOCYTE ADHESION TO CEREBRAL ENDOTHELIUM - EFFECTS OF MEASLES-VIRUS AND HERPES-SIMPLEX-1 VIRUS

被引：31

作者：

BRANKIN, B ^{[1
]}

HART, MN ^{[1
]}

COSBY, SL ^{[1
]}

FABRY, Z ^{[1
]}

ALLEN, IV ^{[1
]}

机构：

[1] UNIV IOWA,COLL MED,DIV NEUROPATHOL,IOWA CITY,IA 52242

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 56卷 / 01期

关键词：

ADHESION MOLECULES; BRAIN MICROVESSEL ENDOTHELIAL CELLS; VIRUS;

D O I：

10.1016/0165-5728(94)00110-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Expression of endothelial cell (EC) adhesion molecules is increased in inflammatory neurological disorders and this may regulate lymphocyte homing to the central nervous system (CNS). Viral encephalitis is characterised by lymphocytic infiltration of the CNS and one mechanism of this response may be EC adhesion molecule induction with consequent inflammatory cell/EC binding. This report characterises the effects of herpes simplex 1 (HSV1) or measles virus (MV) infection of BALB/c brain microvascular EC in vitro on adhesion of naive syngenic splenocytes and levels of ICAM-1. Adhesion was enhanced by 42% for MV-infected cells and by 73% for HSV-1-infected EC. At the multiplicities of infection employed, levels of ICAM-1 were upregulated on HSV-1-infected EC, but not on MV-infected EC. It is concluded that ICAM-1/ligand interactions do not play a role in mediation of MV enhancement of adherence, but represent one mechanism responsible for increased lymphocyte adherence to HSV-1-infected cerebral EC.

引用

页码：1 / 8

页数：8

共 36 条

[1] PATHOGENESIS OF MULTIPLE-SCLEROSIS - THE IMMUNE DIATHESIS AND THE ROLE OF VIRUSES [J].