SULPHATES OF MONOSACCHARIDES AND DERIVATIVES .7. SYNTHESIS OF SOME DISULPHATES AND A NEW SYNTHESIS OF D-GALACTOSE 4-SULPHATE

Sulphation of a sugar derivative with the pyridine-sulphur trioxide reagent in pyridine solution has been shown to be an equilibrium reaction. For polysulphation to occur, it is necessary to use enough reagent to oversaturate the pyridine and to form a reagent-rich, second phase. With these conditions, barium salts of a number of sugar and glycoside disulphates have been prepared by definitive routes. β-d-Galactose 4-sulphate and two d-galactoside 4-sulphates have been synthesized by an improved method. © 1969.