STUDIES ON BINDING OF TETRACYCLINE TO RIBOSOMES

被引：14

作者：

LAST, JA

机构：

[1] Department of Biochemistry, Ohio State University, Columbus, OH

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 195卷 / 02期

关键词：

D O I：

10.1016/0005-2787(69)90657-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The binding of tritiated tetracycline to Escherichia coli ribosomes has been investigated by a Millipore filtration technique. The effects of various conditions such as pH, temperature, and ionic strenght on this binding are reported. Apparently no covalent linkage is formed between the drug and the ribosomes. Evidence will be presented that such binding is due to electrostatic interactions between the drug and some component of the ribosome, possibly RNA. © 1969.

引用

页码：506 / &

共 13 条

[1] DETERMINATION OF CARBON-14 IN AQUEOUS BICARBONATE SOLUTIONS BY LIQUID SCINTILLATION COUNTING TECHNIQUES - APPLICATION TO BIOLOGICAL FLUIDS
BRUNO, GA
CHRISTIAN, JE
[J]. ANALYTICAL CHEMISTRY, 1961, 33 (09) : 1216 - &
[2] STUDIES ON INTRACELLULAR LOCALIZATION OF TETRACYCLINE IN BACTERIA
CONNAMAC.RH
MANDEL, HG
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 166 (02) : 475 - &
[3] BINDING OF TETRACYCLINE TO 30S RIBOSOMES AND TO POLYURIDYLIC ACID
CONNAMACHER, RH
MANDEL, HG
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1965, 20 (01) : 98 - +
[4] STUDIES ON RIBOSOMES OF STREPTOMYCIN-SENSITIVE + RESISTANT STRAINS OF ESCHERICHIA COLI
DAVIES, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (04) : 659 - &
[5] TETRACYCLINE INHIBITION OF CELL-FREE PROTEIN SYNTHESIS .I. BINDING OF TETRACYCLINE TO COMPONENTS OF SYSTEM
DAY, LE
[J]. JOURNAL OF BACTERIOLOGY, 1966, 91 (05) : 1917 - &
[6] BROWN PIGMENTATION (LIPOFUSCINOSIS) OF CANINE INTESTINAL MUSCULARIS
CORDES, DO
MOSHER, AH
[J]. JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1966, 92 (01): : 197 - &
[7] FURTHER EVIDENCE OF TETRACYCLINE BINDING TO ESCHERICHIA COLI RIBOSOMES
DAY, LE
[J]. JOURNAL OF BACTERIOLOGY, 1966, 92 (04) : 1263 - &
[8] THE BINDING OF MAGNESIUM TO MICROSOMAL NUCLEOPROTEIN AND RIBONUCLEIC ACID
EDELMAN, IS
TSO, POP
VINOGRAD, J
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1960, 43 (03) : 393 - 403
[9] SOME EFFECTS OF VARIOUS TETRACYCLINES ON INCORPORATION OF AMINO ACIDS INTO POLYPEPTIDES BY ESCHERICHIA COLI EXTRACTS
LAST, JA
IZAKI, K
SNELL, JF
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 174 (01) : 400 - &
[10] FAILURE OF TETRACYCLINE TO BIND TO ESCHERICHIA COLI RIBOSOMES
LAST, JA
IZAKI, K
SNELL, JF
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 103 (03) : 532 - &

← 1 2 →