A NEW PROTECTED ACYL PROTECTING GROUP FOR EXOCYCLIC AMINO FUNCTIONS OF NUCLEOBASES

被引：24

作者：

DREEFTROMP, CM

HOOGERHOUT, P

VANDERMAREL, GA

VANBOOM, JH

机构：

[1] Gorlaeus Laboratories, 2300 RA Leiden

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(00)94573-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(Tert-butyldiphenylsilyloxymethyl)benzoyl chloride (SiOMB-Cl) reacts with the per-O-trimethylsilylated d-nucleosides C,G and A to give, after removal of the Si(Me)3 groups and 5'-O-protection with 4,4'-dimethoxytrityl chloride (DMT-Cl), the corresponding N-SiOMB-5'-O-DMT derivates, the SiOMB groups of which can easily be removed by fluoride ion. The SiOMB protected nucleosides proved to be suitable building units for the preparation of DNA fragments in solution and on a solid support. © 1990.

引用

页码：427 / 430

页数：4

共 19 条

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