THE SUBSTANCE-P RECEPTOR ANTAGONIST CP-96,345 INTERACTS WITH CA-2+ CHANNELS

被引：95

作者：

SCHMIDT, AW ^{[1
]}

MCLEAN, S ^{[1
]}

HEYM, J ^{[1
]}

机构：

[1] PFIZER INC,CENT RES DIV,DEPT NEUROSCI,GROTON,CT 06340

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 219卷 / 03期

关键词：

CP-96,345; SUBSTANCE-P; CA-2+ CHANNELS;

D O I：

10.1016/0014-2999(92)90498-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The nonpeptide substance P receptor antagonist CP-96,345 was found to displace binding to Ca2+ channel binding sites labelled with either [H-3]desmethoxyverapamil or [H-3]diltiazem and to enhance [H-3]nitrendipine binding. Unlike the substance P receptor antagonist activity of CP-96,345, these effects on Ca2+ channel binding sites were neither stereoselective nor species-dependent. It is concluded that CP-96,345 may act as an antagonist of L-type Ca2+ channels in addition to being a potent NK1 receptor (substance P) antagonist.

引用

页码：491 / 492

页数：2

共 6 条

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MCLEAN, S
GANONG, AH
SEEGER, TF
BRYCE, DK
PRATT, KG
REYNOLDS, LS
SIOK, CJ
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[J]. SCIENCE, 1991, 251 (4992) : 437 - 439
[5] REYNOLDS IJ, 1986, J PHARMACOL EXP THER, V237, P731
[6] A POTENT NONPEPTIDE ANTAGONIST OF THE SUBSTANCE-P (NK1) RECEPTOR
SNIDER, RM
CONSTANTINE, JW
LOWE, JA
LONGO, KP
LEBEL, WS
WOODY, HA
DROZDA, SE
DESAI, MC
VINICK, FJ
SPENCER, RW
HESS, HJ
[J]. SCIENCE, 1991, 251 (4992) : 435 - 437

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