A GENERAL MIXTURE MODEL FOR MAPPING QUANTITATIVE TRAIT LOCI BY USING MOLECULAR MARKERS

被引:94
作者
JANSEN, RC
机构
[1] Centre for Plant Breeding and Reproduction Research (CPRO-DLO), Wageningen, 6700 AA
关键词
EM-ALGORITHM; GENERALIZED LINEAR MODEL; GENETIC LINKAGE MAP; MIXTURE OF DISTRIBUTIONS; MOLECULAR MARKER; QUANTITATIVE TRAIT LOCUS;
D O I
10.1007/BF00222867
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
In a segregating population a quantitative trait may be considered to follow a mixture of (normal) distributions, the mixing proportions being based on Mendelian segregation rules. A general and flexible mixture model is proposed for mapping quantitative trait loci (QTLs) by using molecular markers. A method is discribed to fit the model to data. The model makes it possible to (1) analyse non-normally distributed traits such as lifetimes, counts or percentages in addition to normally distributed traits, (2) reduce environmental variation by taking into account the effects of experimental design factors and interaction between genotype and environment, (3) reduce genotypic variation by taking into account the effects of two or more QTLs simultaneously, (4) carry out a (combined) analysis of different population types, (5) estimate recombination frequencies between markers or use known marker distances, (6) cope with missing marker observations, (7) use markers as covariables in detection and mapping of QTLs, and finally to (8) implement the mapping in standard statistical packages.
引用
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页码:252 / 260
页数:9
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