GEARBOX GENE-EXPRESSION AND GROWTH-RATE

被引：8

作者：

ALDEA, M

GARRIDO, T

TORMO, A

机构：

[1] Department de Ciències Mèdiques Bàsiques, Universitat de Lleida, Lleida, 25006, Rovira Roure

[2] Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, Madrid, 28006

[3] Departamento de Bioquímica y Biología Molecular I, Facultad de Biología, Universidad Complutense de Madrid, Madrid

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 1993年 / 9卷 / 04期

关键词：

CELL DIVISION; GEARBOX PROMOTER; GENE EXPRESSION REGULATION; GROWTH RATE;

D O I：

10.1007/BF00328029

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Regulation of gene expression in prokaryotic cells usually takes place at the level of transcription initiation. Different forms of RNA polymerase recognizing specific promoters are engaged in the control of many prokaryotic regulons. This also seems to be the case for some Escherichia coli genes that are induced at low growth rates and by nutrient starvation. Their gene products are synthesized at levels inversely proportional to growth rate, and this mode of regulation has been termed gearbox gene expression. This kind of growth-rate modulation is exerted by specific transcriptional initiation signals, the gearbox promoters, and some of them depend on a putative new sigma factor (RpoS). Gearbox promoters drive expression of morphogenetic and cell division genes at constant levels per cell and cycle to meet the demands of cell division and septum formation. A mechanism is proposed that could sense the growth rate of the cell to alter gene expression by the action of specific sigma factors

引用

页码：414 / 420

页数：7

共 43 条

[1]

Aldea M., Garrido T., Hernandez-Chico C., Vicente M., Kushner S.R., Induction of a growth-phase-dependent promoter triggers transcription of bolA, an E. coli morphogene, EMBO Journal, 8, pp. 3923-3931, (1989)

[2]

Aldea M., Garrido T., Pla J., Vicente M., Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters, EMBO Journal, 9, pp. 3787-3794, (1990)

[3]

Aldea M., Hernandez-Chico C., De La Campa A.G., Kushner S.R., Vicente M., Identification, cloning, and expression of bolA, an ftsZ-dependent morphogene of Escherichia coli, Journal of Bacteriology, 170, pp. 5169-5176, (1988)

[4]

Bohannon D., Connell N., Keener J., Tormo A., Espinosa-Urgel M., Zambrano M., Kolter R., Stationary-phase inducible “gearbox” promoters: differential effects of katF mutations and role of σ<sup>70</sup>, Journal of Bacteriology, 73, pp. 4482-4492, (1991)

[5]

Connell N., Han Z., Moreno F., Kolter R., An E. coli promoter induced by the cessation of growth, Molecular Microbiology, 1, pp. 195-201, (1987)

[6]

Dassa E., Bouquet P.L., Identification of the gene appA for the acid phosphatase (pH optimum 2.5) of Escherichia coli, Molecular and General Genetics, 200, pp. 68-73, (1985)

[7]

Del Castillo I., Gomez J.M., Moreno F., mrpA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid, Journal of Bacteriology, 172, pp. 437-445, (1990)

[8]

Diaz-Guerra L., Moreno F., San Millan J.L., appR gene product activates transcription of microcin C17 plasmid genes, Journal of Bacteriology, 171, pp. 2906-2908, (1989)

[9]

Dopazo A., Palacios P., Sanchez M., Pla J., Vicente M., An amino-proximal domain required for the localization of FtsQ in the cytoplasmic membrane, and for its biological function in Escherichia coli, Molecular Microbiology, 6, pp. 715-722, (1992)

[10]

Gaal T., Gourse R.L., Guanosine 3′-diphosphate 5′-disphosphate is not required for growth rate-dependent control of rRNA synthesis in Escherichia coli, Proceedings of the National Academy of Sciences of the United States of America, 87, pp. 5533-5537, (1990)

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