SUSCEPTIBILITY OF TENASCIN TO DEGRADATION BY MATRIX METALLOPROTEINASES AND SERINE PROTEINASES

被引：72

作者：

IMAI, K

KUSAKABE, M

SAKAKURA, T

NAKANISHI, I

OKADA, Y

机构：

[1] KANAZAWA UNIV,SCH MED,DEPT PATHOL,KANAZAWA,ISHIKAWA 920,JAPAN

[2] INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,CELL BIOL LAB,TSUKUBA,IBARAKI 305,JAPAN

[3] MIE UNIV,SCH MED,DEPT PATHOL,TSU,MIE 514,JAPAN

来源：

FEBS LETTERS | 1994年 / 352卷 / 02期

关键词：

TENASCIN; MATRIX METALLOPROTEINASE; SERINE PROTEINASE;

D O I：

10.1016/0014-5793(94)00960-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The degradation of tenascin purified from human melanoma cells was examined by treatment with matrix metalloproteinases (MMPs) and serine proteinases. Among eight different types of proteinases examined, MMP-1, -3, and -7, cathepsin G and leukocyte elastase could digest tenascin, but MMP-2, MMP-9 and thrombin did not. This suggests that tenascin may be readily catabolized by extracellular matrix-degrading proteinases found in the pathophysiological conditions.

引用

页码：216 / 218

页数：3

共 21 条

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