IN-VIVO INHIBITION OF SERUM DOPAMINE-BETA-HYDROXYLASE BY CANA2 EDTA INJECTION

被引：6

作者：

DEPARIS, P ^{[1
]}

CAROLDI, S ^{[1
]}

机构：

[1] UNIV PADUA,IST MED LAVORO,I-35127 PADUA,ITALY

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷 / 04期

关键词：

D O I：

10.1177/096032719401300405

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 In humans CaNa(2)EDTA increases urinary excretion of lead as well as that of essential metals such as zinc, ferrum and manganese but not that of copper. 2 We studied the effect of CaNa(2)EDTA injection on serum dopamine-beta-hydroxylase, a copper-dependent enzyme, in three male lead welders hospitalized for suspected lead poisoning. 3 Injection of CaNa(2)EDTA (1000 mg i.v.) resulted in rapid reduction of serum dopamine-beta-hydroxylase activity which returned to normal level within 24 hours. 4 Copper sulphate (8 mu M) but not ethylmaleimide (10 mM) restored in vitro serum dopamine-beta-hydroxylase activity to pre-dosing values which indicates that CaNa(2)EDTA inhibits dopamine-beta-hydroxylase by removing copper from the enzyme. 5 An inverse dose effect relationship between injected CaNa(2)EDTA and residual serum dopamine-beta-hydroxylase activity was observed.

引用

页码：253 / 256

页数：4

共 10 条

[1] EFFECTS OF AN EDTA INFUSION ON THE URINARY ELIMINATION OF SEVERAL ELEMENTS IN HEALTHY-SUBJECTS [J].