SYNTHESIS OF VARIOUS MODEL COMPOUNDS FOR THE CONJUGATED HETEROCYCLIC RING-SYSTEM OF ANTIBIOTIC ROSEOPHILIN

被引：35

作者：

NAKATANI, S ^{[1
]}

KIRIHARA, M ^{[1
]}

YAMADA, K ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR, SAGAMIHARA, KANAGAWA 229, JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 46期

关键词：

D O I：

10.1016/0040-4039(95)01822-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title synthesis was accomplished starting with 3-chloro-2-formylpyrrole. The synthetic scheme featured one-pot preparation of the 4-methoxy-2-(pyrrol-2-yl)furan from the 2-acetoacetyl-pyrrole and coupling reactions of the C-5-position of the 4-methoxy-2-(pyrrol-2-yl)furan with various types of aldehydes and ketones as key steps.

引用

页码：8461 / 8464

页数：4

共 6 条

[1] Hayakawa, Kawakami, Seto, Furihata, Tetrahedron Lett., 33, (1992)
[2] Bellamy, Martz, Streith, An Intriguing Copper Salt Effect upon the Photochemistry of Pyridine-N-oxides. Specific Photoinduced Syntheses of 3-Substituted 2-Formylpyrroles, HETEROCYCLES, 3, (1975)
[3] Ochiai, J. Org. Chem., 18, (1953)
[4] Iwai, Iwashige, Asai, Tomita, Hiraoka, Ide, Chem. Pharm. Bull., 11, (1963)
[5] Wenkert, Goodwin, 4-Formyl-2-cyclohexenone Derivatives, Synthetic Communications, 7, (1977)
[6] Kakushima, Hamel, Frenette, Rokach, J. Org. Chem., 48, (1983)

← 1 →