ALDOSTERONE ANTAGONISTS .2. NEW 7-ALPHA-(ACETYLTHIO)-15,16-METHYLENE SPIROLACTONES

被引:22
作者
NICKISCH, K [1 ]
BITTLER, D [1 ]
LAURENT, H [1 ]
LOSERT, W [1 ]
CASALSSTENZEL, J [1 ]
NISHINO, Y [1 ]
SCHILLINGER, E [1 ]
WIECHERT, R [1 ]
机构
[1] SCHERING AG,BERGKAMEN,FED REP GER
关键词
D O I
10.1021/jm00391a023
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1403 / 1409
页数:7
相关论文
共 18 条
[1]  
ABSHAGEN U, 1976, N-S ARCH PHARMACOL, V296, P37, DOI 10.1007/BF00498838
[2]   GYNECOMASTIA AND SEMEN ABNORMALITIES INDUCED BY SPIRONOLACTONE IN NORMAL MEN [J].
CAMINOSTORRES, R ;
MA, L ;
SNYDER, PJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 45 (02) :255-260
[3]   DETECTION AND COMPARATIVE-EVALUATION OF ALDOSTERONE ANTAGONISTS IN GLUCOCORTICOID-TREATED, ADRENALECTOMIZED RATS [J].
CASALSSTENZEL, J ;
BUSE, M ;
LOSERT, W .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 80 (01) :37-45
[4]   A STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF SPIROLACTONES - CONTRIBUTION OF THE CYCLOPROPANE RING TO ANTIMINERALOCORTICOID ACTIVITY [J].
CHINN, LJ ;
SALAMON, KW ;
DESAI, BN .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (09) :1103-1107
[5]   DIMETHYLSULFOXONIUM METHYLIDE [J].
COREY, EJ ;
CHAYKOVSKY, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (05) :867-&
[6]   SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 8-ALPHA-ESTRADIOL DERIVATIVES [J].
GONZALEZ, FB ;
NEEF, G ;
EDER, U ;
WIECHERT, R ;
SCHILLINGER, E ;
NISHINO, Y .
STEROIDS, 1982, 40 (02) :171-187
[7]   ISOLATION AND IDENTIFICATION OF NOVEL SULFUR-CONTAINING METABOLITES OF SPIRONOLACTONE (ALDACTONE-R) [J].
KARIM, A ;
BROWN, EA .
STEROIDS, 1972, 20 (01) :41-&
[8]  
LOSERT W, 1986, ARZNEIMITTEL-FORSCH, V36-2, P1583
[9]  
NEUMANN F, 1977, ARZNEIMITTEL-FORSCH, V27-1, P296
[10]   ALDOSTERONE ANTAGONISTS .1. SYNTHESIS AND ACTIVITIES OF 6-BETA,7-BETA-15-BETA,16-BETA-DIMETHYLENE STEROIDAL SPIROLACTONES [J].
NICKISCH, K ;
BITTLER, D ;
CASALSSTENZEL, J ;
LAURENT, H ;
NICKOLSON, R ;
NISHINO, Y ;
PETZOLDT, K ;
WIECHERT, R .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (05) :546-550