INCREASED YIELD OF HIGH-TITER VARIANTS OF STREPTOMYCES-GLOMERATUS, PRODUCING ANTHRACYCLINE ANTIBIOTICS OF THE BEROMYCIN GROUP, AFTER TREATMENT WITH PLASMID-CURING AGENTS

被引：6

作者：

BLUMAUEROVA, M ^{[1
]}

MAKSIMOVA, TS ^{[1
]}

GAUSE, GF ^{[1
]}

VANEK, Z ^{[1
]}

机构：

[1] ACAD MED SCI USSR,INST NEW ANTIBIOT,MOSCOW 109801,USSR

来源：

BIOTECHNOLOGY LETTERS | 1979年 / 1卷 / 08期

关键词：

D O I：

10.1007/BF01388189

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The frequency of occurrence of melaninless asporogenous variants with higher antibiotic-producing activity in populations of Streptomyces glomeratus, a producer of beromycins, increased by more than 100-200 times as a result of treatment with plasmid-curing agents (acridine orange or acriflavine), whereas ultraviolet light and nitrous oxide were less effective in this regard. © 1979 Kluwer Academic Publishers.

引用

页码：337 / 341

页数：5

共 8 条

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[2]

GAUSE GF, 1978, ANTIBIOT MED BIOTEK, V23, P483

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KUDINOVA MK, 1972, ANTIBIOT MED BIOTEK, V17, P689

[7] POSSIBLE CONTROL OF FORMATION OF AERIAL MYCELIUM AND ANTIBIOTIC PRODUCTION IN STREPTOMYCES BY EPISOMIC FACTORS [J].

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[8]

Okanishi M., 1979, GENET IND MICROORGAN, P134

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