EVIDENCE THAT 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE IS THE METABOLITE RESPONSIBLE FOR PROGESTERONE ANESTHESIA

被引：50

作者：

MOK, WM ^{[1
]}

KRIEGER, NR ^{[1
]}

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT ANESTHESIA,BOSTON,MA 02115

来源：

BRAIN RESEARCH | 1990年 / 533卷 / 01期

关键词：

5α-Pregnan-3α-ol-20-one; Analgesia; Anesthesia; Anesthetic; General anesthesia; Progesterone; Storoid;

D O I：

10.1016/0006-8993(90)91792-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tadpoles (Rana catesbeiana) were anesthetized with [3H]-progesterone (PG) in order to identify the steroid responsible for anesthesia. PG and its metabolites in brain were resolved (HPLC) and quantitated following sacrifice at different behavioral endpoints. The results support the hypothesis that 5α-pregnan-3α-ol-20-one mediates the loss and the return of the righting response. The observed levels for PG were not consistent with such a role. Neither PG nor 5α-pregnan-3α-ol-20 produced analgesia. © 1990.

引用

页码：42 / 45

页数：4

共 23 条

[1]

BISCHOFF F, 1948, J BIOL CHEM, V174, P663

[2] PROGESTERONE DISTRIBUTION IN THE BRAIN OF THE PMSG TREATED FEMALE RAT [J].

BIXO, M ;

BACKSTROM, T ;

WINBLAD, B .

ACTA PHYSIOLOGICA SCANDINAVICA, 1984, 122 (03) :355-359

[3] ANDROGEN METABOLISM IN BRAIN AND NON-NEURAL TISSUES OF BULLFROG RANA-CATESBEIANA [J].

CALLARD, GV ;

PETRO, Z ;

RYAN, KJ .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1978, 34 (01) :18-25

[4]

FIGDOR SK, 1957, J PHARMACOL EXP THER, V119, P299

[5]

HARRISON NL, 1987, J PHARMACOL EXP THER, V241, P346

[6] ANESTHETIC PROPERTIES OF PREGNANOLONE EMULSION - A COMPARISON WITH ALPHAXOLONE ALPHADOLONE, PROPOFOL, THIOPENTONE AND MIDAZOLAM IN A RAT MODEL [J].

HOGSKILDE, S ;

WAGNER, J ;

CARL, P ;

SORENSEN, MB .

ANAESTHESIA, 1987, 42 (10) :1045-1050

[7] INVIVO SECRETION OF 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE, A POTENT ANESTHETIC STEROID, BY THE ADRENAL-GLAND OF THE RAT [J].

HOLZBAUER, M ;

BIRMINGHAM, MK ;

DENICOLA, AF ;

OLIVERS, JT .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1985, 22 (01) :97-102

[8] ANALGESIC EFFECTS OF THE PROGESTERONE METABOLITE, 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE, AND POSSIBLE MODES OF ACTION IN MICE [J].

KAVALIERS, M ;

WIEBE, JP .

BRAIN RESEARCH, 1987, 415 (02) :393-398

[9] PROPERTIES OF THE HYPOTHALAMIC 5-ALPHA-DIHYDROPROGESTERONE NADH-LINKED AND NADPH-LINKED 3-ALPHA-HYDROXYSTEROID OXIDOREDUCTASE ACTIVITIES [J].

KRAUSE, JE ;

KARAVOLAS, HJ .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1981, 14 (01) :63-69

[10] 3-ALPHA-HYDROXYSTEROID OXIDOREDUCTASE IN RAT-BRAIN [J].

KRIEGER, NR ;

SCOTT, RG .

JOURNAL OF NEUROCHEMISTRY, 1984, 42 (03) :887-890

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