EVIDENCE FOR A POSSIBLE ROLE FOR SEROTONERGIC SYSTEMS IN THE CONTROL OF CEREBRAL BLOOD-FLOW

被引：26

作者：

MCBEAN, DE

SHARKEY, J

RITCHIE, IM

KELLY, PAT

机构：

[1] Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh

来源：

BRAIN RESEARCH | 1990年 / 537卷 / 1-2期

基金：

英国惠康基金;

关键词：

LOCAL CEREBRAL BLOOD FLOW; LOCAL CEREBRAL GLUCOSE UTILIZATION; METHYLENEDIOXYAMPHETAMINE; FLOW-METABOLISM COUPLING;

D O I：

10.1016/0006-8993(90)90374-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebral blood flow and glucose utilisation were measured in rats using [C-14]iodoantipyrine and [C-14]2-deoxyglucose quantitative autoradiography respectively following repeated exposure to the serotonergic neurotoxin methylenedioxyamphetamine. In both control and treated animals blood flow and glucose use were similarly correlated but the ratio was increased following lesion. Some focal increases in flow were greatly in excess of metabolic demand. These results are consistent with a cerebrovascular vasoconstrictor role for serotonin.

引用

页码：307 / 310

页数：4

共 23 条

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