THE EFFECTS OF MEASUREMENT ERRORS IN THE PLASMA RADIOACTIVITY CURVE ON PARAMETER-ESTIMATION IN POSITRON EMISSION TOMOGRAPHY

被引：70

作者：

CHEN, K

HUANG, SC

YU, DC

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DIV NUCL MED & BIOPHYS,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,NUCL MED LAB,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT BIOMATH,LOS ANGELES,CA 90024

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 1991年 / 36卷 / 09期

关键词：

D O I：

10.1088/0031-9155/36/9/003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The effects of three error sources in plasma curve measurements on parameter estimation in kinetic analysis of positron emission tomography (PET) fluorodeoxyglucose (FDG) data are investigated by computer simulation. The three error sources are: (1) measurement noise in the radioactivity concentrations of plasma samples; (2) linear interpolation between adjacent plasma sampling points of the plasma time activity curve; and (3) incorrect weights used for the least-squares regression. All three error sources are found to increase the variability of the parameter estimates, with the first one a primary error source in normal PET FDG studies. The performance of five estimation methods which account for the error sources are evaluated. When the noise variances of the plasma and the tissue measurements are not known, an iterative weighting procedure is shown to give accurate and reliable estimates.

引用

页码：1183 / 1200

页数：18

共 21 条

[1] MODELS FOR INVIVO KINETIC INTERACTIONS OF DOPAMINE D2-NEURORECEPTORS AND 3-(2'-[F-18]FLUOROETHYL)SPIPERONE EXAMINED WITH POSITRON EMISSION TOMOGRAPHY [J].