MECHANISM OF HUMAN PLACENTAL AROMATASE - A NEW ACTIVE-SITE MODEL

被引：73

作者：

OH, SS ^{[1
]}

ROBINSON, CH ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,725 N WOLFE ST,BALTIMORE,MD 21205

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1993年 / 44卷 / 4-6期

关键词：

D O I：

10.1016/0960-0760(93)90242-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on Akhtar's ferric peroxide mechanism and on recent studies in our own laboratory, we present a detailed proposal for aromatase action. This picture can account for the known stereochemical consequences at C-19 observed by others using isotopes of hydrogen and oxygen. The postulated process involves anchoring of the 19-hydroxymethyl and 19-oxo groups at the active site by a glutamate residue, which also serves to activate the 19-oxo group for attack by ferric peroxy species in the third oxidative step.

引用

页码：389 / 397

页数：9

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