HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CHLORHEXIDINE AND P-CHLOROANILINE USING A SPECIALTY COLUMN AND A PHOTODIODE-ARRAY DETECTOR

被引：17

作者：

GAVLICK, WK

机构：

[1] Calgon Vestal Laboratories, St. Louis, MO 63166-0147

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 623卷 / 02期

关键词：

D O I：

10.1016/0021-9673(92)80379-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method has been developed for the separation of chlorhexidine and its known degradation product, p-chloroaniline. These amine-containing compounds can be separated without the addition of ion-pairing reagents and/or amine modifiers if the proper specialty column is selected. A photodiode-array detector was used to acquire spectral data and demonstrate the importance of the mobile phase pH when optimizing the response of p-chloroaniline.

引用

页码：375 / 380

页数：6

共 11 条

[1]

BACHNER J, 1981, Journal of High Resolution Chromatography and Chromatography Communications, V4, P132, DOI 10.1002/jhrc.1240040311

[2] SIMULTANEOUS DETERMINATION OF CHLORHEXIDINE, TETRACAINE AND THEIR DEGRADATION PRODUCTS BY ION-PAIR LIQUID-CHROMATOGRAPHY [J].