ALTERNATIVE STRATEGIES TOWARDS THE IDENTIFICATION OF CHEMICAL LEAD COMPOUNDS BY RATIONAL DESIGN

被引：3

作者：

HORWELL, DC ^{[1
]}

LENNON, IC ^{[1
]}

ROBERTS, E ^{[1
]}

机构：

[1] ADDENBROOKES HOSP, PARKE DAVIS NEUROSCI RES CTR, CAMBRIDGE CB2 2QB, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0960-894X(94)80030-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Non-peptide ligands are described that are rationally derived from dipeptides known to be key in binding to the appropriate peptide receptors. These derivatives are shown to exhibit affinity and selectivity for the receptors under study and may be designated as chemical leads for further exploitation in the design of potential therapeutic agents.

引用

页码：525 / 530

页数：6

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