CONSTRAINED PEPTIDES AS BINDING ENTITIES

被引：103

作者：

LADNER, RC

机构：

[1] Protein Engineering Corporation, Cambridge, MA 02138

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0167-7799(00)88997-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Displaying proteins and peptides on genetic packages and selecting packages that display high-affinity binders allows large numbers of peptidyl compounds to be tested for binding to targets. Phage-displayed libraries of unstructured peptides (UPs) have yielded binders for some targets, but not for many others, Therefore, more attention is being paid to peptidyl compounds that have varied regions that are subject to conformational constraint.

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页码：426 / 430

页数：5

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