BRAIN-DERIVED NEUROTROPHIC FACTOR PRETREATMENT EXERTS A PARTIALLY PROTECTIVE EFFECT AGAINST GLUTAMATE-INDUCED NEUROTOXICITY IN CULTURED RAT CORTICAL-NEURONS

被引：54

作者：

SHIMOHAMA, S

TAMURA, Y

AKAIKE, A

TSUKAHARA, T

OHARA, O

WATANABE, S

KIMURA, J

机构：

[1] FUKUYAMA UNIV,FAC PHARM & PHARMACEUT SCI,DEPT NEUROPHARMACOL,FUKUYAMA,HIROSHIMA 72902,JAPAN

[2] NATL CARDIOVASC CTR,DEPT CEREBROVASC SURG,OSAKA,OSAKA 565,JAPAN

[3] SHIONOGI & CO LTD,SHIONOGI RES LABS,OSAKA,OSAKA 553,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 164卷 / 1-2期

关键词：

RECOMBINANT BRAIN-DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; GLUTAMATE; NEUROTOXICITY; CULTURE; CORTEX; PROTECTION;

D O I：

10.1016/0304-3940(93)90856-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of recombinant brain-derived neurotrophic factor (BDNF) on cultured rat cortical neurons was examined. Brief exposure of cortical neurons to glutamate followed by incubation with glutamate-free medium reduced cell viability by 60-70% when compared with the control value. Simultaneous addition of recombinant BDNF to rat cortical cultures with glutamate did not affect this reduction of cell viability. However, 24 h pretreatment of rat cortical cultures with recombinant BDNF resulted in a significant reduction of glutamate-induced neuronal damage. These findings suggest that BDNF can protect cortical neurons against glutamate-induced neurotoxicity.

引用

页码：55 / 58

页数：4

共 20 条

[1] CHOLECYSTOKININ-INDUCED PROTECTION OF CULTURED CORTICAL-NEURONS AGAINST GLUTAMATE NEUROTOXICITY [J].