CEREBRAL AND RETINAL VASCULAR COMPLICATIONS OF INFLAMMATORY BOWEL-DISEASE

被引：106

作者：

SCHNEIDERMAN, JH

SHARPE, JA

SUTTON, DMC

机构：

[1] TORONTO WESTERN HOSP, DIV NEUROL, NEUROOPHTHALMOL UNIT, TORONTO M5T 2S8, ONTARIO, CANADA

[2] TORONTO WESTERN HOSP, DIV HEMATOL, TORONTO M5T 2S8, ONTARIO, CANADA

[3] UNIV TORONTO, FAC MED, DEPT MED, TORONTO M5S 1A1, ONTARIO, CANADA

来源：

ANNALS OF NEUROLOGY | 1979年 / 5卷 / 04期

关键词：

D O I：

10.1002/ana.410050405

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recurrent retinal branch artery occlusions, carotid thromboembolism, cerebral venous thrombosis, transient brainstem ischemia, and massive brainstem and cerebral infarction complicated the course of inflammatory bowel disease in 5 patients. Three patients had ulcerative colitis and 2 had regional enteritis. The usual risk factors for stroke were absent. Neuropathological examination in 1 patient showed in situ thrombosis of small cerebral and brainstem arteries and veins. Coagulation studies showed thrombocytosis, short partial thromboplastin times, and elevation of fibrinogen and Factor VIII levels. Platelet counts and coagulation factors returned toward normal after control of intestinal inflammation in each of the 4 surviving patients. Inflammatory bowel disease can be accompanied by a hypercoagulable state that predisposes to stroke. Copyright © 1979 American Neurological Association

引用

页码：331 / 337

页数：7

共 34 条

[1] PROGESTATIONAL AGENTS AND BLOOD-COAGULATION .7. THROMBOEMBOLIC AND OTHER COMPLICATIONS OF ORAL-CONTRACEPTIVE THERAPY IN RELATIONSHIP TO PRETREATMENT LEVELS OF BLOOD-COAGULATION FACTORS - SUMMARY REPORT OF A 10-YEAR STUDY [J].