DECREASED DENSITY OF BENZODIAZEPINE RECEPTORS IN LYMPHOCYTES OF ANXIOUS PATIENTS - REVERSAL AFTER CHRONIC DIAZEPAM TREATMENT

被引：78

作者：

FERRARESE, C

APPOLLONIO, I

FRIGO, M

PEREGO, M

PIOLTI, R

TRABUCCHI, M

FRATTOLA, L

机构：

[1] UNIV MILAN,OSPED SAN GERARDO TINTORI,DEPT NEUROL,NEUROL CLIN,VIA DONIZETTI 106,I-20052 MONZA,ITALY

[2] UNIV ROME,DEPT EXPTL MED,I-00100 ROME,ITALY

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1990年 / 82卷 / 02期

关键词：

anxiety disorder; diazepam; lymphocyte; peripheral benzodiazepine receptor;

D O I：

10.1111/j.1600-0447.1990.tb01376.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Peripheral‐type benzodiazepine receptors were measured in human circulating lymphocytes using 3H‐PK 11195 as specific ligand. In a group of outpatients with anxiety disorders a significant decrease of receptor density (– 37%) was found compared with age‐matched controls. In these patients long‐term diazepam treatment restored binding density to normal levels: the effect persisted after drug withdrawal. Acute i.v. diazepam administration did not change receptor density. The observed receptor changes could reflect a down‐regulation phenomenon and indicate that lymphocyte function reflect central nervous events. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：169 / 173

页数：5

共 40 条

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