DISSIMILAR EFFECTS OF LITHIUM ISOTOPES ON MOTILITY IN RATS

被引：17

作者：

LIEBERMAN, KW

ALEXANDER, GJ

STOKES, P

机构：

[1] CORNELL UNIV,COLL MED,DEPT BIOCHEM,NEW YORK,NY 10021

[2] NEW YORK STATE PSYCHIAT INST,NEUTROTOXICOL RES UNIT,NEW YORK,NY 10032

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 06期

关键词：

Isotopes; Lithium; Lithium-6; Lithium-7; Mobility;

D O I：

10.1016/0091-3057(79)90070-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Male Wistar rats were injected twice daily with chlorides of pure lithium isotopes, either Li-6 or Li-7. While both salts decreased motility, the salt of Li-6 initially produced a more profound effect than the salt of Li-7. This differential effect of the isotopes proved to be time dependent and was most evident on the third day of treatment. Li-6 is likely to become a valuable tool in basic psychopharmacological research. It may possess therapeutic and/or toxic properties that are different from those of lithium salts currently used in treatment of mania. © 1979.

引用

页码：933 / 935

页数：3

共 12 条

[1] ALEXANDER GJ, 1978, PHARMAC BIOCH BEHAV, V8, P253
[2] DISTRIBUTION AND KINETICS OF COEDTA IN SMOOTH MUSCLE AND ITS USE AS AN EXTRACELLULAR MARKER
BRADING, AF
JONES, AW
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1969, 200 (02): : 387 - &
[3] COTTON FA, 1975, ADV INORGANIC CHEM
[4] EFFECTS OF LITHIUM CARBONATE ON TURNOVER AND METABOLISM OF NOREPINEPHRINE IN RAT BRAIN - CORRELATION TO GROSS BEHAVIORAL EFFECTS
GREENSPA.K
ARONOFF, MS
BOGDANSK.DF
[J]. PHARMACOLOGY, 1970, 3 (03) : 129 - &
[5] EFFECT OF LITHIUM ON REARING ACTIVITY IN RATS
JOHNSON, FN
WORMINGTON, S
[J]. NATURE-NEW BIOLOGY, 1972, 235 (57): : 159 - +
[6] JOHNSON FN, 1971, EXPERIENTIA, V28, P533
[7] LIEBERMAN KW, 1977, AM CHEM SOC M CHICAG
[8] PEREZCRUET J, 1971, J PHARMACOL EXP THER, V178, P325
[9] EFFECT OF PROLONGED LITHIUM ADMINISTRATION ON ACTIVITY, REACTIVITY, AND ENDURANCE IN RAT
SMITH, DF
SMITH, HB
[J]. PSYCHOPHARMACOLOGIA, 1973, 30 (01): : 83 - 88
[10] BIOGENIC-AMINES AND EFFECT OF SHORT-TERM LITHIUM ADMINISTRATION ON OPEN-FIELD ACTIVITY IN RATS
SMITH, DF
[J]. PSYCHOPHARMACOLOGIA, 1975, 41 (03): : 295 - 300

← 1 2 →