EFFECTS OF COCAINE ON DOPAMINE-RECEPTOR GENE-EXPRESSION - A STUDY IN THE POSTMORTEM HUMAN BRAIN

被引：41

作者：

MEADORWOODRUFF, JH ^{[1
]}

LITTLE, KY ^{[1
]}

DAMASK, SP ^{[1
]}

MANSOUR, A ^{[1
]}

WATSON, SJ ^{[1
]}

机构：

[1] UNIV N CAROLINA, DEPT PSYCHIAT, CHAPEL HILL, NC 27514 USA

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 34卷 / 06期

关键词：

RECEPTORS; DOPAMINE; MESSENGER RNA; IN-SITU HYBRIDIZATION; COCAINE; RECEPTOR BINDING; HUMAN BRAIN;

D O I：

10.1016/0006-3223(93)90178-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of chronic cocaine exposure on dopamine D1 and D2 receptor gene expression in the human brain were studied in postmortem samples from chronic cocaine abusing and matched control subjects. Using in situ hybridization and receptor autoradiography to examine messenger ribonucleic acid (RNA) and binding sites, respectively, neither D1 nor D2 receptor expression was found to be changed in the nucleus accumbens, caudate, putamen, or substantia nigra of the cocaine-exposed subjects. Although chronic cocaine exposure can produce alterations in dopaminergic neurotransmission, sustained compensatory changes in dopamine receptor expression do not appear to occur in the human.

引用

页码：348 / 355

页数：8

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