RELIABILITY OF IN-VIVO VOLUME MEASURES OF HIPPOCAMPUS AND OTHER BRAIN STRUCTURES USING MRI

被引：104

作者：

BARTZOKIS, G

MINTZ, J

MARX, P

OSBORN, D

GUTKIND, D

CHIANG, F

PHELAN, CK

MARDER, SR

机构：

[1] Research Service, VA Medical Center West Los Angeles (Brentwood Division), Los Angeles

[2] The Psychiatry Service, VA Medical Center West Los Angeles (Brentwood Division), Los Angeles

[3] Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles

[4] Department of Radiology, Harbor-UCLA Medical Center, Torrance

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 07期

关键词：

MAGNETIC RESONANCE IMAGING (MRI); BRAIN VOLUMES; HIPPOCAMPUS; AMYGDALA; TEST-RETEST RELIABILITY;

D O I：

10.1016/0730-725X(93)90218-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Volume reductions of the hippocampus are associated with Alzheimer's disease, schizophrenia, and epilepsy. We used clinically available MRI methods (2D acquisition; inversion recovery and calculated T2 images; 3 mm contiguous slices) that optimize image contrast, quality, and resolution and standardized positioning protocols to maximize the in vivo accuracy (test-retest reliability) of brain volume measurements in volunteers who were scanned two or three times. Volunteers were scanned in the same MRI instrument (intrascanner reliability) as well as in two different instruments (interscanner reliability). A single rater obtained brain volume measures of seven contiguous slices centered on the anterior commissure. The in vivo intrascanner reliability for measures of anterior hippocampus and ventricular volumes was very good, with reliability coefficients [intraclass r (r(xx))] ranging between .855 and .997, and a median coefficient of variation (CV) of 6.4%. Reliability was good for amygdala (r(xx) of .740 and .764) and for total frontal and temporal lobe volumes and white matter volume measures (r(xx) ranging between .640 and .823, median coefficient of variation was 3.2%). Overall, interscanner reliability was also good. We discuss the implications of our results relative to the possible clinical utility of hippocampal quantification and the feasibility of prospective studies aimed at quantifying progressive neurodegeneration.

引用

页码：993 / 1006

页数：14

共 44 条

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