THE BETA-2,4-DIMETHYL-3-PENTYL ESTER AS A NEW PROTECTING GROUP FOR ASPARTIC-ACID THAT PREVENTS BASE-CATALYZED ASPARTIMIDE FORMATION IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引：16

作者：

KARLSTROM, AH

UNDEN, AE

机构：

[1] Department of Neurochemistry and Neurotoxicology, Stockholm University

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 22期

关键词：

D O I：

10.1016/0040-4039(95)00639-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new protecting group for aspartic acid that effectively prevents base-catalyzed aspartimide formation is presented. The 2,4-dimethyl-3-pentyl ester is particularly useful in orthogonal peptide synthesis when the removal of base-labile protecting groups is accompanied by aspartimide formation.

引用

页码：3909 / 3912

页数：4

共 7 条

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PEDROSO, E
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[4] STEPHENSON RC, 1989, J BIOL CHEM, V264, P6164
[5] MECHANISMS FOR THE REMOVAL OF BENZYL PROTECTING GROUPS IN SYNTHETIC PEPTIDES BY TRIFLUOROMETHANESULFONIC ACID TRIFLUOROACETIC-ACID DIMETHYL SULFIDE
TAM, JP
HEATH, WF
MERRIFIELD, RB
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (17) : 5242 - 5251
[6] TAM JP, 1979, TETRAHEDRON LETT, V42, P4033
[7] WANG SS, 1974, INT J PEPT PROT RES, V6, P103

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