INDUCTION OF AUTOANTI-IDIOTYPIC ANTIBODIES AND EFFECTS ON THE SUBSEQUENT IMMUNE-RESPONSE

被引：10

作者：

WUILMART, C

WIKLER, M

URBAIN, J

机构：

[1] Université Libre de Bruxelles, Laboratory of Animal Physiology, B 1640 Rhode-St-Genése, 67, rue des Chevaux

来源：

MOLECULAR IMMUNOLOGY | 1979年 / 16卷 / 12期

关键词：

D O I：

10.1016/0161-5890(79)90042-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rabbits hyperimmunized with Micrococcus luteus produce two unrelated antibody populations of restricted affinity. After isolation, one specific Ab population was subjected to preparative isoelectric focusing and one single isoelectric fraction was used to induce iso- and autoanti-idiotypic antibodies. It is shown that individual rabbits are able to synthesize antibodies directed against their own idiotypic determinants. Moreover, such an induction of autoanti-idiotypic antibodies is shown to modulate the idiotypic expression when the animal is subsequently restimulated by the original antigen. © 1979.

引用

页码：1085 / 1092

页数：8

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