DIPHOSPHONATES INHIBIT HYDROXYAPATITE DISSOLUTION IN VITRO AND BONE RESORPTION IN TISSUE CULTURE AND IN VIVO

被引：710

作者：

FLEISCH, H

RUSSELL, RGG

FRANCIS, MD

机构：

[1] Department of Pathophysiology, University of Berne

[2] Laboratory for Experimental Surgery, Davos

[3] Miami Valley Laboratories, Procter and Gamble Company, Cincinnati

来源：

SCIENCE | 1969年 / 165卷 / 3899期

关键词：

D O I：

10.1126/science.165.3899.1262

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two diphosphonates containing the P-C-P bond, Cl2C(PO 3HNa)2 and H2C(PO3HNa)2 retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.

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页码：1262 / &

相关论文

共 18 条

[1] THYROCALCITONIN INHIBITION OF BONE RESORPTION INDUCED BY PARATHYROID HORMONE IN TISSUE CULTURE [J].

ALIAPOUL.MA ;

GOLDHABE.P ;

MUNSON, PL .

SCIENCE, 1966, 151 (3708) :330-&

[2] GROWTH OF EMBRYONIC AVIAN AND MAMMALIAN TIBIAE ON A RELATIVELY SIMPLE CHEMICALLY DEFINED MEDIUM [J].

BIGGERS, JD ;

HEYNER, S ;

GWATKIN, RBL .

EXPERIMENTAL CELL RESEARCH, 1961, 25 (01) :41-&

[3] ISOLATION OF INORGANIC PYROPHOSPHATE FROM BOVINE AND HUMAN TEETH [J].

BISAZ, S ;

RUSSELL, RGG ;

FLEISCH, H .

ARCHIVES OF ORAL BIOLOGY, 1968, 13 (06) :683-&

[4]

CARTIER P, 1957, B SOC CHIM BIOL, V39, P169

[5] MECHANISM OF CALCIFICATION - INHIBITORY ROLE OF PYROPHOSPHATE [J].

FLEISCH, H ;

BISAZ, S .

NATURE, 1962, 195 (4844) :911-&

[6]

FLEISCH H, 1966, P SOC EXP BIOL MED, V122, P317

[7] PREVENTION BY A DIPHOSPHONATE OF IMMOBILIZATION OSTEOPOROSIS IN RATS [J].

FLEISCH, H ;

RUSSELL, RGG ;

SIMPSON, B ;

MUHLBAUER, RC .

NATURE, 1969, 223 (5202) :211-+

[8] EFFECT OF CONDENSED PHOSPHATES ON CALCIFICATION OF CHICK EMBRYO FEMURS IN TISSUE CULTURE [J].

FLEISCH, H ;

STRAUMANN, F ;

SCHENK, R ;

BISAZ, S ;

ALLGOWER, M .

AMERICAN JOURNAL OF PHYSIOLOGY, 1966, 211 (03) :821-+

[9] EFFECT OF PYROPHOSPHATE ON HYDROXYAPATITE AND ITS IMPLICATIONS IN CALCIUM HOMEOSTASIS [J].

FLEISCH, H ;

RUSSEL, RGG ;

STRAUMANN, F .

NATURE, 1966, 212 (5065) :901-+

[10] MECHANISMS OF CALCIFICATION - ROLE OF COLLAGEN, POLYPHOSPHATES, AND PHOSPHATASE [J].

FLEISH, H ;

NEUMAN, WF .

AMERICAN JOURNAL OF PHYSIOLOGY, 1961, 200 (06) :1296-&