DENDRITIC ACTION-POTENTIALS ACTIVATED BY NMDA RECEPTOR-MEDIATED EPSPS IN CA1 HIPPOCAMPAL PYRAMIDAL CELLS

被引：26

作者：

POOLOS, NP

KOCSIS, JD

机构：

[1] VET ADM MED CTR,NEUROSCI RES CTR,PVA EPVA,W HAVEN,CT 06516

[2] YALE UNIV,SCH MED,FACHBEREICH NEUROL,NEW HAVEN,CT 06510

[3] YALE UNIV,SCH MED,DEPT NEUROANAT,NEW HAVEN,CT 06510

[4] STANFORD UNIV,NEUROSCI PROGRAM,STANFORD,CA 94305

来源：

BRAIN RESEARCH | 1990年 / 524卷 / 02期

关键词：

Burst firing; CA1; hippocampus; Dendrite; Intradendritic; n-Methyl-d-aspartate; Short-term potentiation;

D O I：

10.1016/0006-8993(90)90714-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intradendritic recordings were obtained in rat CA1 hippocampal pyramidal cells. Repetitive stimulation produced substantial short-term potentiation of the dendritic excitatory postsynaptic potential (EPSP) which was partly attributable to activation of n-methyl-d-aspartate receptors. Accompanying the potentiated synaptic response were Na+-mediated spikes which appeared to originate at multiple sites in the dendritic arbor. These discrete dendritic action potentials are rarely distinguishable in somatic recordings but may contribute to the subthreshold response at the pyramidal cell body. In addition, dendritic spikes may interact with other voltage-dependent dendritic conductances. © 1990.

引用

页码：342 / 346

页数：5

共 14 条

[1]

BENARDO LS, 1982, J NEUROSCI, V2, P1614

[2] ELECTRO-PHYSIOLOGICAL PROPERTIES OF INVITRO PURKINJE-CELL DENDRITES IN MAMMALIAN CEREBELLAR SLICES [J].