COMPARATIVE EFFECT OF CLONIDINE AND GROWTH-HORMONE (GH)-RELEASING HORMONE ON GH SECRETION IN ADULT PATIENTS ON CHRONIC GLUCOCORTICOID THERAPY

被引:23
作者
GIUSTINA, A
BUFFOLI, MG
BUSSI, AR
DOGA, M
GIRELLI, A
PIZZOCOLO, G
POZZI, A
WEHRENBERG, WB
机构
[1] UNIV BRESCIA,CATTEDRA CHIM,I-25125 BRESCIA,ITALY
[2] UNIV WISCONSIN,DEPT HLTH SCI,MILWAUKEE,WI 53201
关键词
CLONIDINE; GROWTH HORMONE (GH); GH-RELEASING HORMONE; SOMATOSTATIN; GLUCOCORTICOIDS; IMMUNOSUPPRESSION; ADRENERGIC SYSTEM;
D O I
10.1055/s-2007-1003302
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Glucocorticoids are thought to inhibit growth hormone (GH) secretion through an enhancement of endogenous somatostatin tone. The aim of our study was to evaluate the effects of GH-releasing hormone (GHRH) and clonidine, an alpha-2-adrenergic agonist which increases GH secretion acting at the hypothalamic level with an unknown mechanism, on GH secretion in seven adult patients (3M, 4F) with non endocrine diseases and on daily immunosuppressive glucocorticoid therapy. Eleven normal subjects (7M, 4F) served as controls. Steroid-treated patients showed a blunted GH response to GHRH (GH peak 8.3 +/- 3-mu-g/L) with respect to normal subjects (GH peak 19.3 +/- 2.4-mu-g/L). The GH responses to clonidine were also blunted (p < 0.05) in steroid-treated patients (GH peak 5.8 +/- 2.8-mu-g/L) with respect to normal subjects (GH peak 17.6 +/- 2.3-mu-g/L). No significant differences between the GH responses to GHRH and clonidine were observed either in steroid-treated or in normal subjects. Clonidine is not able to enhance GH secretion similar to GHRH in patients chronically treated with steroids. It can be hypothesized that clonidine does not elicit GH secretion decreasing hypothalamic somatostatin tone.
引用
收藏
页码:240 / 243
页数:4
相关论文
共 21 条
[1]   INTERACTION OF CLONIDINE AND GHRH ON GH SECRETION INVIVO AND INVITRO [J].
ALBAROTH, J ;
LOSA, M ;
SPIESS, Y ;
SCHOPOHL, J ;
MULLER, OA ;
VONWERDER, K .
CLINICAL ENDOCRINOLOGY, 1989, 30 (05) :485-491
[2]   EFFECTS OF PROLONGED CORTISONE THERAPY ON THE STATURAL GROWTH, SKELETAL MATURATION AND METABOLIC STATUS OF CHILDREN [J].
BLODGETT, FM ;
BURGIN, L ;
IEZZONI, D ;
GRIBETZ, D ;
TALBOT, NB .
NEW ENGLAND JOURNAL OF MEDICINE, 1956, 254 (14) :636-641
[3]   COMPARISON OF EFFECTS OF LONG-TERM CORTICOTROPIN AND CORTICOSTEROID TREATMENT ON RESPONSES OF PLASMA GROWTH-HORMONE, ACTH, AND CORTICOSTEROID TO HYPOGLYCEMIA [J].
DALY, JR ;
FLETCHER, MR ;
GLASS, D ;
CHAMBERS, DJ ;
BITENSKY, L ;
CHAYEN, J .
BRITISH MEDICAL JOURNAL, 1974, 2 (5918) :521-524
[4]  
DIEGUEZ C, 1988, CLIN ENDOCRINOL, V28, P109
[5]  
GILAD I, 1979, LANCET, V2, P278
[6]   EFFECTS OF CALCITONIN ON GH RESPONSE TO PYRIDOSTIGMINE IN COMBINATION WITH HGHRH (1-29) NH2 IN NORMAL ADULT SUBJECTS [J].
GIUSTINA, A ;
BODINI, C ;
BOSSONI, S ;
DOGA, M ;
GIRELLI, A ;
PIZZOCOLO, G ;
WEHRENBERG, WB .
CLINICAL ENDOCRINOLOGY, 1990, 33 (03) :375-380
[7]   THE ROLE OF CHOLINERGIC TONE IN MODULATING THE GROWTH-HORMONE RESPONSE TO GROWTH HORMONE-RELEASING HORMONE IN NORMAL MAN [J].
GIUSTINA, A ;
BOSSONI, S ;
BODINI, C ;
DOGA, M ;
GIRELLI, A ;
BUFFOLI, MG ;
SCHETTINO, M ;
WEHRENBERG, WB .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1991, 40 (05) :519-523
[8]   ACUTE EFFECTS OF CORTISONE-ACETATE ON GROWTH-HORMONE RESPONSE TO GROWTH HORMONE-RELEASING HORMONE IN NORMAL ADULT SUBJECTS [J].
GIUSTINA, A ;
DOGA, M ;
BODINI, C ;
GIRELLI, A ;
LEGATI, F ;
BOSSONI, S ;
ROMANELLI, G .
ACTA ENDOCRINOLOGICA, 1990, 122 (02) :206-210
[9]   PYRIDOSTIGMINE BLOCKS THE INHIBITORY EFFECT OF GLUCOCORTICOIDS ON GROWTH HORMONE-RELEASING HORMONE STIMULATED GROWTH-HORMONE SECRETION IN NORMAL MAN [J].
GIUSTINA, A ;
GIRELLI, A ;
DOGA, M ;
BODINI, C ;
BOSSONI, S ;
ROMANELLI, G ;
WEHRENBERG, WB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 71 (03) :580-584
[10]  
HARTOG M, 1964, LANCET, V2, P376